Ревматоид артритли беморларда яллиғланиш олди цитокинлар гени полиморфизмининг прогностик аҳамияти

Ushbu dissertatsiya

Asosiy mavzular

• RЭВМАТОИД АРТРИТЛИ БЕМОРЛАРДА ЯЛЛИҒЛАНИШ ОЛДИ ЦИТОКИНЛАР ГЕНИ ПОЛИМОРФИЗМИНИНГ ПРОГНОСТИК АҲАМИЯТИ: Mazmunan, ushbu dissertatsiya revmatoid artrit (RA) va undifferensiallangan artrit (NDA) kasalliklarining rivojlanishida sitokin genlari polimorfizmining prognostik ahamiyatini o'rganishga bag'ishlangan. Tadqiqotda RA va NDA bemorlarida TNF-α, IL-6 kabi sitokinlarning darajasi, ularning kasallik kechishidagi o'rni, shuningdek, IL17A, IL17F, IL23 va TLR2 genlar polimorfizmining kasallikning prognoziga ta'siri o'rganilgan. Tadqiqot natijalari asosida RA va NDAni erta aniqlash va rivojlanishini bashorat qilish uchun diagnostik mezonlar va algoritmlar ishlab chiqilgan. Tadqiqot RA ning erta tashxisi, davolash va oldini olish choralarini takomillashtirishga qaratilgan bo'lib, bemorlar hayot sifatini yaxshilashga hissa qo'shadi.
• Prognostic significance of proinflammatory cytokine genes polymorphism in patients with rheumatoid arthritis: The dissertation explores the prognostic significance of proinflammatory cytokine gene polymorphism in patients with rheumatoid arthritis (RA) and undifferentiated arthritis (NDA). The study investigates the levels of cytokines such as TNF-α and IL-6 in RA and NDA patients, their role in disease progression, and the impact of IL17A, IL17F, IL23, and TLR2 gene polymorphism on disease prognosis. Based on the research findings, diagnostic criteria and algorithms have been developed for early detection and prediction of RA and NDA. The study aims to improve early diagnosis, treatment, and prevention of RA, thereby enhancing the quality of life for patients.